A Guideline Summary has also been published. Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand were released in December 2019. Fortunately, N-acetylcysteine (NAC) is a safe and effective antidote which if used correctly prevents serious hepatic injury after paracetamol overdose. While paracetamol is safe in normal doses, it is hepatotoxic and potentially fatal in overdose. It is also common to see accidental paediatric ingestion, unintentional self-administered supratherapeutic ingestions or intentional self-poisoning in the Emergency Department. ![]() Paracetamol is widely used for its analgesic/anti-pyretic effects.
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